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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM167878
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
11±n/a nM
Comments
extracted
Citation
 Guzzo, PR; Surman, MD; Zhu, L Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof US Patent  US9073925 Publication Date 7/7/2015 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM167878
Synonyms:
US9073925, 7
Type:
Small organic molecule
Emp. Form.:
C27H25F3N4O2
Mol. Mass.:
494.5082
SMILES:
Cn1c2C3CCN(CC3)Cc2c2ccc(cc12)-n1ccc(OCc2ccc(nc2)C(F)(F)F)cc1=O |(7.11,-1.2,;6.34,.13,;7.24,1.38,;8.78,1.38,;9.8,2.54,;9.52,4.05,;8.16,4.78,;7.62,3.67,;8.78,2.68,;6.75,4.18,;6.34,2.62,;4.87,2.15,;3.54,2.92,;2.21,2.15,;2.21,.61,;3.54,-.16,;4.87,.61,;.87,-.16,;.87,-1.7,;-.46,-2.47,;-1.79,-1.7,;-3.13,-2.47,;-4.46,-1.7,;-5.79,-2.47,;-7.13,-1.7,;-8.46,-2.47,;-8.46,-4.01,;-7.13,-4.78,;-5.79,-4.01,;-9.8,-4.78,;-11.13,-5.55,;-11.13,-4.01,;-9.8,-6.32,;-1.79,-.16,;-.46,.61,;-.46,2.15,)|
Structure:
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