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Target
Oligo-1,6-glucosidase IMA1
Ligand
BDBM173546
Substrate
n/a
Meas. Tech.
Baker's Yeast alpha-Glucosidase Inhibition Assay
pH
6.8±n/a
Temperature
310.15±n/a K
IC50
3.897e+4± 9.9e+2 nM
Comments
extracted
Citation
 Zawawi, NK; Taha, M; Ahmat, N; Ismail, NH; Wadood, A; Rahim, F; Rehman, AU Synthesis, in vitro evaluation and molecular docking studies of biscoumarin thiourea as a new inhibitor of a-glucosidases. Bioorg Chem 63:36-44 (2015) [PubMed]  Article 
Target
Name:
Oligo-1,6-glucosidase IMA1
Synonyms:
α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase
Type:
Protein
Mol. Mass.:
68577.59
Organism:
Saccharomyces cerevisiae S288c (Baker's yeast)
Description:
n/a
Residue:
589
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
  
Inhibitor
Name:
BDBM173546
Synonyms:
1-(4-(bis(4-Hydroxy-2-oxo-2H-chromen-3-yl)methyl)phenyl)-3-(4-bromophenyl)-thiourea (3)
Type:
Small organic molecule
Emp. Form.:
C32H21BrN2O6S
Mol. Mass.:
641.488
SMILES:
Oc1c(C(c2ccc(NC(=S)Nc3ccc(Br)cc3)cc2)c2c(O)c3ccccc3oc2=O)c(=O)oc2ccccc12
Structure:
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