Reaction Details Report a problem with these data
Target
Cathepsin S
Ligand
BDBM175206
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
IC50
9±n/a nM
Citation
 Cai, J; Bennett, DJ; Jones, PS 1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derivatives US Patent  US9115126 Publication Date 8/25/2015 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM175206
Synonyms:
US9115126, Example 4b
Type:
Small organic molecule
Emp. Form.:
C27H26F3N7O
Mol. Mass.:
521.5368
SMILES:
Cc1cccc(n1)N1CCC(CCOc2ccc(cc2C(F)(F)F)-c2cc3n(C)nnc3c(n2)C#N)CC1
Structure:
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