Reaction Details Report a problem with these data
Target
Urease
Ligand
BDBM175355
Substrate
n/a
Meas. Tech.
Urease Inhibition Assay
Ki
2.200e+4± 2e+1 nM
IC50
4.13e+4± 5e+2 nM
Citation
 Khan, A; Hashim, J; Arshad, N; Khan, I; Siddiqui, N; Wadood, A; Ali, M; Arshad, F; Khan, KM; Choudhary, MI Dihydropyrimidine based hydrazine dihydrochloride derivatives as potent urease inhibitors. Bioorg Chem 64:85-96 (2016) [PubMed]  Article 
Target
Name:
Urease
Synonyms:
UREA_CANEN | Urea amidohydrolase
Type:
Enzyme
Mol. Mass.:
90746.20
Organism:
Canavalia ensiformis (Jack bean) (Horse bean)
Description:
P07374
Residue:
840
Sequence:
MKLSPREVEKLGLHNAGYLAQKRLARGVRLNYTEAVALIASQIMEYARDGEKTVAQLMCLGQHLLGRRQVLPAVPHLLNAVQVEATFPDGTKLVTVHDPISRENGELQEALFGSLLPVPSLDKFAETKEDNRIPGEILCEDECLTLNIGRKAVILKVTSKGDRPIQVGSHYHFIEVNPYLTFDRRKAYGMRLNIAAGTAVRFEPGDCKSVTLVSIEGNKVIRGGNAIADGPVNETNLEAAMHAVRSKGFGHEEEKDASEGFTKEDPNCPFNTFIHRKEYANKYGPTTGDKIRLGDTNLLAEIEKDYALYGDECVFGGGKVIRDGMGQSCGHPPAISLDTVITNAVIIDYTGIIKADIGIKDGLIASIGKAGNPDIMNGVFSNMIIGANTEVIAGEGLIVTAGAIDCHVHYICPQLVYEAISSGITTLVGGGTGPAAGTRATTCTPSPTQMRLMLQSTDDLPLNFGFTGKGSSSKPDELHEIIKAGAMGLKLHEDWGSTPAAIDNCLTIAEHHDIQINIHTDTLNEAGFVEHSIAAFKGRTIHTYHSEGAGGGHAPDIIKVCGIKNVLPSSTNPTRPLTSNTIDEHLDMLMVCHHLDREIPEDLAFAHSRIRKKTIAAEDVLNDIGAISIISSDSQAMGRVGEVISRTWQTADKMKAQTGPLKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPSFFGTKPEMVIKGGMVAWADIGDPNASIPTPEPVKMRPMYGTLGKAGGALSIAFVSKAALDQRVNVLYGLNKRVEAVSNVRKLTKLDMKLNDALPEITVDPESYTVKADGKLLCVSEATTVPLSRNYFLF
  
Inhibitor
Name:
BDBM175355
Synonyms:
Methyl 6-methyl-4-(p-tolyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (10)
Type:
Small organic molecule
Emp. Form.:
C14H16N2O2S
Mol. Mass.:
276.354
SMILES:
COC(=O)C1=C(C)NC(=S)NC1c1ccc(C)cc1 |c:4|
Structure:
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