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Target
Mitogen-activated protein kinase 1 [L235A]
Ligand
BDBM176676
Substrate
n/a
Meas. Tech.
Fluorescence Quenching Assay
Kd
90±20 nM
Citation
 Shapiro, PS; MacKerell, Jr., AD; Fletcher, S Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK) US Patent  US9115122 Publication Date 8/25/2015 
Target
Name:
Mitogen-activated protein kinase 1 [L235A]
Synonyms:
ERK2(L235A) | Erk2 | MK01_MOUSE | Mapk | Mapk1 | Prkm1
Type:
n/a
Mol. Mass.:
41236.57
Organism:
Mus musculus (mouse)
Description:
P63085[L235A]
Residue:
358
Sequence:
MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQANHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM176676
Synonyms:
US9115122, 2.3.2
Type:
Small organic molecule
Emp. Form.:
C10H10O5S2
Mol. Mass.:
274.313
SMILES:
O=S(=O)(OC1CS(=O)(=O)C=C1)c1ccccc1 |c:9|
Structure:
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