Reaction Details
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Lysosomal acid glucosylceramidase
Ligand
BDBM175504
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
4.5±n/a
Ki
2480±50 nM
IC50
5990±110 nM
EC50
60700±110 nM
Comments
extracted
Citation
Wustman, BA Method for the treatment of neurological disorders by enhancing the activity of beta-glucocerebrosidase US Patent US9119845 Publication Date 9/1/2015 More Info.:
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Beta-glucocerebrosidase | GBA1_MOUSE | Gba | Gba1
Type:
Enzyme
Mol. Mass.:
57628.24
Organism:
Mus musculus (Mouse)
Description:
P17439
Residue:
515
Sequence:
MAARLIGFFLFQAVSWAYGAQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQKLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLDDQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLNRSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ
Inhibitor
Name:
BDBM175504
Synonyms:
US9119845, 5
Type:
Small organic molecule
Emp. Form.:
C9H19NO4
Mol. Mass.:
205.2515
SMILES:
COCCN1CC[C@@H](O)[C@H](O)[C@H]1CO |r|
Structure:
