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Target
Plasminogen activator inhibitor 1
Ligand
BDBM175548
Substrate
n/a
Meas. Tech.
Fluorometric Plate Assay
pH
7.8±n/a
Temperature
296.15±n/a K
IC50
90±n/a nM
Comments
extracted
Citation
 Lawrence, DA; Emal, C; Cale, J; Su, EJ; Warnock, M; Li, S; Cupp, JA Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism US Patent  US9120744 Publication Date 9/1/2015 
Target
Name:
Plasminogen activator inhibitor 1
Synonyms:
Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1
Type:
Enzyme
Mol. Mass.:
45064.00
Organism:
Homo sapiens (Human)
Description:
P05121
Residue:
402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
  
Inhibitor
Name:
BDBM175548
Synonyms:
US9120744, CDE-059
Type:
Small organic molecule
Emp. Form.:
C12H12N2O8S2
Mol. Mass.:
376.362
SMILES:
Oc1ccc(cc1O)S(=O)(=O)NNS(=O)(=O)c1ccc(O)c(O)c1
Structure:
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