Reaction Details Report a problem with these data
Target
Maternal embryonic leucine zipper kinase
Ligand
BDBM177156
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
1.4±n/a nM
Comments
extracted
Citation
 Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent  US9120749 Publication Date 9/1/2015 
Target
Name:
Maternal embryonic leucine zipper kinase
Synonyms:
KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)
Type:
Enzyme
Mol. Mass.:
74665.45
Organism:
Homo sapiens (Human)
Description:
Q14680
Residue:
651
Sequence:
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
  
Inhibitor
Name:
BDBM177156
Synonyms:
US9120749, 522
Type:
Small organic molecule
Emp. Form.:
C25H26N6O
Mol. Mass.:
426.5135
SMILES:
CN[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(cc12)-c1cnc(nc1)C#N)C(=O)C1CC1 |r,wU:2.1,wD:5.8,(-1.79,5.26,;-1.79,3.72,;-.7,2.63,;.78,3.03,;1.87,1.94,;1.48,.45,;-.01,.05,;-1.1,1.14,;2.56,-.64,;2.56,-2.18,;3.9,-2.95,;3.9,-4.49,;2.56,-5.26,;1.23,-4.49,;-.1,-5.26,;-1.44,-4.49,;-1.44,-2.95,;-.1,-2.18,;1.23,-2.95,;-2.77,-2.18,;-4.1,-2.95,;-5.44,-2.18,;-5.44,-.64,;-4.1,.13,;-2.77,-.64,;-6.77,.13,;-8.11,.9,;5.23,-2.18,;5.23,-.64,;6.57,-2.95,;7.34,-4.28,;8.11,-2.95,)|
Structure:
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