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Target
Maternal embryonic leucine zipper kinase
Ligand
BDBM177273
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
1.2±n/a nM
Comments
extracted
Citation
 Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent  US9120749 Publication Date 9/1/2015 
Target
Name:
Maternal embryonic leucine zipper kinase
Synonyms:
KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)
Type:
Enzyme
Mol. Mass.:
74665.45
Organism:
Homo sapiens (Human)
Description:
Q14680
Residue:
651
Sequence:
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
  
Inhibitor
Name:
BDBM177273
Synonyms:
US9120749, 639
Type:
Small organic molecule
Emp. Form.:
C27H30ClN3O3
Mol. Mass.:
479.998
SMILES:
COc1cc(cc(Cl)c1O)-c1ccc2ncc(C(=O)C3CC3)c(NC3CCC(C)(N)CC3)c2c1 |(-8.11,-1.61,;-6.77,-2.38,;-5.44,-1.61,;-4.1,-2.38,;-2.77,-1.61,;-2.77,-.07,;-4.1,.7,;-4.1,2.24,;-5.44,-.07,;-6.77,.7,;-1.44,-2.38,;-1.44,-3.92,;-.1,-4.69,;1.23,-3.92,;2.56,-4.69,;3.9,-3.92,;3.9,-2.38,;5.23,-1.61,;5.23,-.07,;6.57,-2.38,;7.34,-3.71,;8.11,-2.38,;2.56,-1.61,;2.56,-.07,;1.48,1.02,;1.87,2.51,;.78,3.6,;-.7,3.2,;-2.19,3.6,;-1.1,4.69,;-1.1,1.71,;-.01,.62,;1.23,-2.38,;-.1,-1.61,)|
Structure:
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