Reaction Details Report a problem with these data
Target
Maternal embryonic leucine zipper kinase
Ligand
BDBM177387
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
1.5±n/a nM
Comments
extracted
Citation
 Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent  US9120749 Publication Date 9/1/2015 
Target
Name:
Maternal embryonic leucine zipper kinase
Synonyms:
KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)
Type:
Enzyme
Mol. Mass.:
74665.45
Organism:
Homo sapiens (Human)
Description:
Q14680
Residue:
651
Sequence:
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
  
Inhibitor
Name:
BDBM177387
Synonyms:
US9120749, 753
Type:
Small organic molecule
Emp. Form.:
C28H31Cl2N3O3
Mol. Mass.:
528.47
SMILES:
CC(=O)c1cnc2ccc(cc2c1N[C@H]1CC[C@H](CN2CCC(O)C2)CC1)-c1cc(Cl)c(O)c(Cl)c1 |r,wU:17.19,wD:14.15,(6.67,-4.28,;5.33,-3.51,;5.33,-1.97,;4,-4.28,;4,-5.82,;2.67,-6.59,;1.33,-5.82,;,-6.59,;-1.33,-5.82,;-1.33,-4.28,;,-3.51,;1.33,-4.28,;2.67,-3.51,;2.67,-1.73,;1.33,-.96,;1.33,.58,;,1.35,;-1.33,.58,;-2.67,1.35,;-2.67,2.89,;-3.91,3.79,;-3.44,5.26,;-1.9,5.26,;-1.13,6.59,;-1.42,3.79,;-1.33,-.96,;,-1.73,;-2.67,-3.51,;-2.67,-1.97,;-4,-1.2,;-4,.34,;-5.33,-1.97,;-6.67,-1.2,;-5.33,-3.51,;-6.67,-4.28,;-4,-4.28,)|
Structure:
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