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Target
C-X-C chemokine receptor type 1
Ligand
BDBM177694
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
3350±n/a nM
Citation
 Musicki, B; Aubert, J; Rossio, P; Schuppli-Nollet, M; Clary, L; Boiteau, J Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases US Patent  US9120772 Publication Date 9/1/2015 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM177694
Synonyms:
US9120772, 6
Type:
Small organic molecule
Emp. Form.:
C25H29N3O6
Mol. Mass.:
467.5143
SMILES:
CN(C)C(=O)c1cccc(Nc2c(NC(c3ccc(C)o3)C3(C)CCOCC3)c(=O)c2=O)c1O
Structure:
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