Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM177798
Substrate
n/a
Meas. Tech.
Fluorescence Polarisation Assay
pH
7.4±n/a
IC50
18±n/a nM
Comments
extracted
Citation
 Le Diguarher, T; Casara, P; Starck, J; Henlin, J; Davidson, JE; Murray, JB; Graham, CJ; Chen, I; Geneste, O; Hickman, J; Depil, S; Le Tiran, A; Nyerges, M; De Nanteuil, G Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them US Patent  US9120791 Publication Date 9/1/2015 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
BCL2_MOUSE | Bcl-2 | Bcl2
Type:
Protein
Mol. Mass.:
26409.44
Organism:
Mus musculus (Mouse)
Description:
P10417
Residue:
236
Sequence:
MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPAVHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM177798
Synonyms:
US9120791, Example 16 | US9603854, 16
Type:
Small organic molecule
Emp. Form.:
C47H47N5O6
Mol. Mass.:
777.906
SMILES:
C[C@H]1COCCN1C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2OCOc2cc1-c1cc(C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ccc3c2)c2CCCCn12
Structure:
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