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Target
Phospholipase D
Ligand
BDBM50229961
Substrate
n/a
Meas. Tech.
pH-Stat Assay
pH
8±n/a
IC50
65±0.0 nM
Comments
extracted
Citation
 Djakpa, H; Kulkarni, A; Barrows-Murphy, S; Miller, G; Zhou, W; Cho, H; Török, B; Stieglitz, K Identifying New Drug Targets for Potent Phospholipase D Inhibitors: Combining Sequence Alignment, Molecular Docking, and Enzyme Activity/Binding Assays. Chem Biol Drug Des 87:714-29 (2016) [PubMed]  Article 
Target
Name:
Phospholipase D
Synonyms:
PLD_STRCW | Phospholipase D (PLD_SC) | pld
Type:
Protein
Mol. Mass.:
59647.22
Organism:
Streptomyces chromofuscus
Description:
Q8KRU5
Residue:
556
Sequence:
MTSRYRSSEAHQGLASFSPRRRTVVKAAAATAVLAGPLAAALPARATTGTPAFLHGVASGDPLPDGVLLWTRVTPTADATPGSGLGPDTEVGWTVATDKAFTNVVAKGSTTATAASDHTVKADIRGLAPATDHWFRFSAGGTDSPAGRARTAPAADAAVAGLRFGVVSCANWEAGYFAAYRHLAARGDLDAWLHLGDYIYEYGAGEYGTRGTSVRSHAPAHEILTLADYRVRHGRYKTDPDLQALHAAAPVVAIWDDHEIANDTWSGGAENHTEGVEGAWAARQAAAKQAYFEWMPVRPAIAGTTYRRLRFGKLADLSLLDLRSFRAQQVSLGDGDVDDPDRTLTGRAQLDWLKAGLKSSDTTWRLVGNSVMIAPFAIGSLSAELLKPLAKLLGLPQEGLAVNTDQWDGYTDDRRELLAHLRSNAIRNTVFLTGDIHMAWANDVPVNAGTYPLSASAATEFVVTSVTSDNLDDLVKVPEGTVSALASPVIRAANRHVHWVDTDRHGYGVLDITAERAQMDYYVLSDRTQAGATASWSRSYRTRSGTQRVERTYDPE
  
Inhibitor
Name:
BDBM50229961
Synonyms:
1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 1-(tert-butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (4) | 1-NA-PP1 | 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (4) | 1-tert-butyl-3-naphthalen-1-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine | CHEMBL264406 | US10544104, Compound 1 | US11247972, Compound 1 | US9765037, Compound 1
Type:
Small organic molecule
Emp. Form.:
C19H19N5
Mol. Mass.:
317.3877
SMILES:
CC(C)(C)n1nc(-c2cccc3ccccc23)c2c(N)ncnc12
Structure:
Search PDB for entries with ligand similarity: