Reaction Details Report a problem with these data
Target
Phospholipase D
Ligand
BDBM123752
Substrate
n/a
Meas. Tech.
pH-Stat Assay
pH
8±n/a
IC50
875±0.0 nM
Comments
extracted
Citation
 Djakpa, H; Kulkarni, A; Barrows-Murphy, S; Miller, G; Zhou, W; Cho, H; Török, B; Stieglitz, K Identifying New Drug Targets for Potent Phospholipase D Inhibitors: Combining Sequence Alignment, Molecular Docking, and Enzyme Activity/Binding Assays. Chem Biol Drug Des 87:714-29 (2016) [PubMed]  Article 
Target
Name:
Phospholipase D
Synonyms:
PLD_STRCW | Phospholipase D (PLD_SC) | pld
Type:
Protein
Mol. Mass.:
59647.22
Organism:
Streptomyces chromofuscus
Description:
Q8KRU5
Residue:
556
Sequence:
MTSRYRSSEAHQGLASFSPRRRTVVKAAAATAVLAGPLAAALPARATTGTPAFLHGVASGDPLPDGVLLWTRVTPTADATPGSGLGPDTEVGWTVATDKAFTNVVAKGSTTATAASDHTVKADIRGLAPATDHWFRFSAGGTDSPAGRARTAPAADAAVAGLRFGVVSCANWEAGYFAAYRHLAARGDLDAWLHLGDYIYEYGAGEYGTRGTSVRSHAPAHEILTLADYRVRHGRYKTDPDLQALHAAAPVVAIWDDHEIANDTWSGGAENHTEGVEGAWAARQAAAKQAYFEWMPVRPAIAGTTYRRLRFGKLADLSLLDLRSFRAQQVSLGDGDVDDPDRTLTGRAQLDWLKAGLKSSDTTWRLVGNSVMIAPFAIGSLSAELLKPLAKLLGLPQEGLAVNTDQWDGYTDDRRELLAHLRSNAIRNTVFLTGDIHMAWANDVPVNAGTYPLSASAATEFVVTSVTSDNLDDLVKVPEGTVSALASPVIRAANRHVHWVDTDRHGYGVLDITAERAQMDYYVLSDRTQAGATASWSRSYRTRSGTQRVERTYDPE
  
Inhibitor
Name:
BDBM123752
Synonyms:
3‐(naphthalen‐1‐yl)‐1‐phenylpyrazolo[3,4‐ d]pyrimidin‐4‐amine (10) | 3-(naphthalen-1-yl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (10)
Type:
Small organic molecule
Emp. Form.:
C21H15N5
Mol. Mass.:
337.3773
SMILES:
Nc1ncnc2n(nc(-c3cccc4ccccc34)c12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: