Reaction Details Report a problem with these data
Target
Beta-lactamase SHV-1
Ligand
BDBM50021959
Substrate
n/a
Meas. Tech.
Cell Free Inhibition Assay
pH
7±n/a
Temperature
310.15±n/a K
IC50
30.3±n/a nM
Comments
extracted
Citation
 Bulusu, AR Substituted clavulanic acid US Patent  US9120808 Publication Date 9/1/2015 
Target
Name:
Beta-lactamase SHV-1
Synonyms:
BLA1_ECOLX | Beta-lactamase (SHV-1) | bla | shv1
Type:
Enzyme
Mol. Mass.:
31226.68
Organism:
Escherichia coli
Description:
P0AD63
Residue:
286
Sequence:
MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR
  
Inhibitor
Name:
BDBM50021959
Synonyms:
CHEMBL777 | MM 14151 | US9120808, Clavulanic acid potassium salt | antibiotic MM 14151 | clavulanic acid
Type:
Small organic molecule
Emp. Form.:
C8H9NO5
Mol. Mass.:
199.1608
SMILES:
OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C(O)=O |r|
Structure:
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