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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM180028
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Assay
Temperature
310.15±n/a K
IC50
>6250±n/a nM
Comments
extracted
Citation
 Cisar, JS; Grice, CA; Jones, TK; Niphakis, MJ; Chang, JW; Lum, KM; Cravatt, BF Carbamate compounds and of making and using same US Patent  US9133148 Publication Date 9/15/2015 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH1_MOUSE | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Hydrolase; single-pass membrane protein; homodimer
Mol. Mass.:
63227.28
Organism:
Mus musculus (mouse)
Description:
Mouse brain membranes were used in the assay.
Residue:
579
Sequence:
MVLSEVWTALSGLSGVCLACSLLSAAVVLRWTRSQTARGAVTRARQKQRAGLETMDKAVQRFRLQNPDLDSEALLALPLLQLVQKLQSGELSPEAVLFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHASTLGLSLNEGVTSESDCVVVQVLKLQGAVPFVHTNVPQSMLSYDCSNPLFGQTMNPWKPSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKSCVYGQTAVQLSVGPMARDVDSLALCMKALLCEDLFRLDSTIPPLPFREEIYRSSRPLRVGYYETDNYTMPTPAMRRAVMETKQSLEAAGHTLVPFLPNNIPYALEVLSAGGLFSDGGCSFLQNFKGDFVDPCLGDLVLVLKLPRWFKKLLSFLLKPLFPRLAAFLNSMCPRSAEKLWELQHEIEMYRQSVIAQWKAMNLDVVLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMEHYKGYFGDMWDNILKKGMKKGIGLPVAVQCVALPWQEELCLRFMREVERLMTPEKRPS
  
Inhibitor
Name:
BDBM180028
Synonyms:
US9133148, 9s
Type:
Small organic molecule
Emp. Form.:
C20H25F6N3O4
Mol. Mass.:
485.4206
SMILES:
COc1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)N1CCOCC1
Structure:
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