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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM180723
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
1.714±n/a nM
Citation
 Gobbi, L; Jaeschke, G; Roche, O; Sarmiento, RM; Steward, L Dual modulators of 5HT2A and D3 receptors US Patent  US8829029 Publication Date 9/9/2014 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM180723
Synonyms:
US8829029, 23
Type:
Small organic molecule
Emp. Form.:
C28H32FN3O4
Mol. Mass.:
493.5698
SMILES:
Fc1ccc2c(noc2c1)C1CCN(CC[C@H]2CC[C@@H](CC2)NC(=O)c2ccc3OCOc3c2)CC1 |r,wU:19.24,wD:16.17,(-4.99,-7.48,;-5.39,-5.99,;-4.3,-4.9,;-4.7,-3.41,;-6.18,-3.01,;-6.58,-1.53,;-8.07,-1.13,;-8.76,-3.7,;-7.27,-4.1,;-6.87,-5.59,;-5.49,-.44,;-4.01,-.84,;-2.92,.25,;-3.32,1.74,;-2.23,2.83,;-.74,2.43,;.35,3.52,;1.84,3.12,;2.93,4.21,;2.53,5.7,;1.04,6.1,;-.05,5.01,;3.62,6.79,;5.1,6.39,;6.19,7.48,;5.5,4.9,;4.41,3.81,;4.81,2.32,;6.3,1.93,;7,.55,;8.52,.79,;8.76,2.32,;7.39,3.01,;6.99,4.5,;-4.8,2.14,;-5.89,1.05,)|
Structure:
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