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Target
D(3) dopamine receptor
Ligand
BDBM180708
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
4.525±n/a nM
Citation
 Gobbi, L; Jaeschke, G; Roche, O; Sarmiento, RM; Steward, L Dual modulators of 5HT2A and D3 receptors US Patent  US8829029 Publication Date 9/9/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM180708
Synonyms:
US8829029, 8
Type:
Small organic molecule
Emp. Form.:
C28H34FN3O3
Mol. Mass.:
479.5863
SMILES:
COc1ccc(cc1)C(=O)N[C@H]1CC[C@H](CCN2CCC(CC2)c2noc3cc(F)ccc23)CC1 |r,wU:11.11,wD:14.15,(6.3,-.65,;7.38,.44,;6.99,1.93,;5.5,2.32,;5.1,3.81,;6.19,4.9,;7.68,4.5,;8.07,3.01,;5.79,6.39,;6.88,7.48,;4.3,6.79,;3.21,5.7,;3.61,4.21,;2.52,3.12,;1.04,3.52,;-.05,2.43,;-1.54,2.83,;-2.63,1.74,;-2.23,.25,;-3.32,-.84,;-4.81,-.44,;-5.21,1.05,;-4.12,2.14,;-5.9,-1.53,;-7.38,-1.13,;-8.07,-3.7,;-6.59,-4.1,;-6.19,-5.59,;-4.7,-5.99,;-4.3,-7.48,;-3.61,-4.9,;-4.01,-3.41,;-5.5,-3.01,;.64,5.01,;1.73,6.1,)|
Structure:
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