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Target
D(3) dopamine receptor
Ligand
BDBM180724
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
2.438±n/a nM
Citation
 Gobbi, L; Jaeschke, G; Roche, O; Sarmiento, RM; Steward, L Dual modulators of 5HT2A and D3 receptors US Patent  US8829029 Publication Date 9/9/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM180724
Synonyms:
US8829029, 24
Type:
Small organic molecule
Emp. Form.:
C22H30FN3O2
Mol. Mass.:
387.4909
SMILES:
CC(=O)N[C@H]1CC[C@H](CCN2CCC(CC2)c2noc3ccc(F)cc23)CC1 |r,wU:4.3,wD:7.7,(8,-5.77,;6.67,-5,;5.33,-5.77,;6.67,-3.46,;5.33,-2.7,;4,-3.47,;2.67,-2.7,;2.67,-1.16,;1.33,-.39,;1.33,1.15,;,1.92,;-1.33,1.15,;-2.67,1.92,;-2.67,3.46,;-1.33,4.23,;,3.46,;-4,4.23,;-4,5.77,;-6.67,5.77,;-6.67,4.23,;-8,3.46,;-8,1.92,;-6.67,1.15,;-6.67,-.39,;-5.33,1.92,;-5.33,3.46,;4,-.38,;5.33,-1.16,)|
Structure:
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