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Target
D(3) dopamine receptor
Ligand
BDBM180745
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
4±n/a nM
Citation
 Gobbi, L; Jaeschke, G; Roche, O; Sarmiento, RM; Steward, L Dual modulators of 5HT2A and D3 receptors US Patent  US8829029 Publication Date 9/9/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM180745
Synonyms:
US8829029, 42B
Type:
Small organic molecule
Emp. Form.:
C30H44ClN3O3
Mol. Mass.:
530.142
SMILES:
CO[C@]1(C)CC[C@H](CC(=O)N[C@H]2CC[C@H](CCN3CCC(CC3)c3noc4cc(Cl)ccc34)CC2)CC1 |r,wU:11.10,6.6,2.1,wD:14.14,2.2,(10.2,-8.06,;9.8,-6.57,;8.47,-5.8,;7.14,-6.57,;9.8,-5.03,;9.8,-3.49,;8.47,-2.72,;8.47,-1.18,;7.14,-.41,;7.14,1.13,;5.8,-1.18,;4.47,-.41,;3.13,-1.18,;1.8,-.41,;1.8,1.13,;.47,1.9,;.47,3.44,;-.87,4.21,;-.87,5.75,;-2.2,6.52,;-3.53,5.75,;-3.53,4.21,;-2.2,3.44,;-4.87,6.52,;-4.87,8.06,;-7.53,8.06,;-7.53,6.52,;-8.87,5.75,;-8.87,4.21,;-10.2,3.44,;-7.53,3.44,;-6.2,4.21,;-6.2,5.75,;3.13,1.9,;4.47,1.13,;7.14,-3.49,;7.14,-5.03,)|
Structure:
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