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Target
D(3) dopamine receptor
Ligand
BDBM180755
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
1.95±n/a nM
Citation
 Gobbi, L; Jaeschke, G; Roche, O; Sarmiento, RM; Steward, L Dual modulators of 5HT2A and D3 receptors US Patent  US8829029 Publication Date 9/9/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM180755
Synonyms:
US8829029, 50
Type:
Small organic molecule
Emp. Form.:
C25H31FN4O3S
Mol. Mass.:
486.602
SMILES:
Fc1ccc2c(noc2c1)C1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2cccnc2)CC1 |r,wU:19.24,wD:16.17,(-7.34,-6.06,;-7.34,-4.52,;-6,-3.75,;-6,-2.21,;-7.34,-1.44,;-7.34,.1,;-8.67,.87,;-10,-1.44,;-8.67,-2.21,;-8.67,-3.75,;-6,.87,;-4.67,.1,;-3.33,.87,;-3.33,2.41,;-2,3.18,;-.67,2.41,;.67,3.18,;2,2.41,;3.33,3.18,;3.33,4.72,;2,5.49,;.67,4.72,;4.67,5.49,;6,4.72,;6.77,6.06,;5.23,3.39,;7.34,3.95,;7.34,2.41,;8.67,1.64,;10,2.41,;10,3.95,;8.67,4.72,;-4.67,3.18,;-6,2.41,)|
Structure:
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