Reaction Details Report a problem with these data
Target
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Ligand
BDBM181109
Substrate
BDBM181111
Meas. Tech.
PEPCK Assay (PEP to OAA)
Temperature
298.15±0 K
Ki
3.7e+4± 3e+3 nM
Citation
 Balan, MD; Mcleod, MJ; Lotosky, WR; Ghaly, M; Holyoak, T Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry 54:5878-87 (2015) [PubMed]  Article 
Target
Name:
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Synonyms:
Cytosolic phosphoenolpyruvate carboxykinase (cPEPCK) | PCKGC_RAT | PEPCK-C | Pck1 | Phosphoenolpyruvate carboxykinase (PEPCK) | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | Phosphoenolpyruvate carboxylase
Type:
Protein
Mol. Mass.:
69414.48
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
622
Sequence:
MPPQLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYGRLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSVLEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKVIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKEDALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIERELRALKQRISQM
  
Inhibitor
Name:
BDBM181109
Synonyms:
3-Mercaptopicolinic acid (MPA)
Type:
Small organic molecule
Emp. Form.:
C6H5NO2S
Mol. Mass.:
155.174
SMILES:
OC(=O)c1ncccc1S
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM181111
Synonyms:
PEP
Type:
Small organic molecule
Emp. Form.:
C3H4O6P
Mol. Mass.:
167.0346
SMILES:
OP(O)(=O)OC(=C)C([O-])=O
Structure:
Search PDB for entries with ligand similarity: