Reaction Details Report a problem with these data
Target
Porphobilinogen deaminase
Ligand
BDBM181149
Substrate
n/a
Meas. Tech.
Enzymatic assay
pH
8±n/a
Temperature
310.15±n/a K
Ki
3e+3±n/a nM
Comments
extracted
Citation
 Millet Aguilar-Galindo, O; Laín Torre, A Use of inhibitors of porphobilinogen deaminase in the treatment of congenital erythropoietic porphyria US Patent  US9138423 Publication Date 9/22/2015 
Target
Name:
Porphobilinogen deaminase
Synonyms:
HEM3_HUMAN | HMBS | PBGD | Porphobilinogen deaminase (PBGD) | UPS
Type:
Enyzyme
Mol. Mass.:
39334.14
Organism:
Homo sapiens (Human)
Description:
P08397
Residue:
361
Sequence:
MSGNGNAAATAEENSPKMRVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGITARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQLNDAH
  
Inhibitor
Name:
BDBM181149
Synonyms:
US9138423, 2,5-dimethyl-1H-pyrrole
Type:
Small organic molecule
Emp. Form.:
C6H9N
Mol. Mass.:
95.1424
SMILES:
Cc1ccc(C)[nH]1
Structure:
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