Reaction Details Report a problem with these data
Target
Delta-type opioid receptor
Ligand
BDBM97715
Substrate
n/a
Meas. Tech.
Beta-Opioid Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
18180±n/a nM
Comments
extracted
Citation
 Tsuno, N; Whitehead, JW; Yao, J Substituted-quinoxaline-type bridged-piperidine compounds as ORL-1 modulators US Patent  US9145408 Publication Date 9/29/2015 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM97715
Synonyms:
US8476271, 96 | US8846929, 356 | US9145408, 356
Type:
Small organic molecule
Emp. Form.:
C28H39N3O3
Mol. Mass.:
465.6276
SMILES:
OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3C2CCCCCCCCCCC2)c1=O |r|
Structure:
Search PDB for entries with ligand similarity: