Reaction Details Report a problem with these data
Target
Opioid growth factor receptor-like protein 1
Ligand
BDBM182733
Substrate
n/a
Meas. Tech.
ORL-1 GTPgammaS Binding Assay
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
1667.1±18.4 nM
Comments
extracted
Citation
 Tsuno, N; Whitehead, JW; Yao, J Substituted-quinoxaline-type bridged-piperidine compounds as ORL-1 modulators US Patent  US9145408 Publication Date 9/29/2015 
Target
Name:
Opioid growth factor receptor-like protein 1
Synonyms:
OGFRL1 | OGRL1_HUMAN | Opioid Receptor-Like Receptor (ORL-1) | Opioid growth factor receptor-like protein 1 (ORL-1) | Opioid growth factor receptor-like protein 1 (ORL1) | Opioid receptor-like (ORL-1) | Opioid receptor-like (ORL1) | Opioid receptor-like protein 1 (OGL1) | Opioid receptor-like receptor (ORL1)
Type:
Protein
Mol. Mass.:
51247.53
Organism:
Homo sapiens (Human)
Description:
Q5TC84
Residue:
451
Sequence:
MGNLLGGVSFREPTTVEDCDSTWQTDSEPEPEEPGPGGGSEGPGQESEQPAQPPEQAGGRPGASPAPDEDAEAAGAEQGGDSTEATAKPKRSFYAARDLYKYRHQYPNFKDIRYQNDLSNLRFYKNKIPFKPDGVYIEEVLSKWKGDYEKLEHNHTYIQWLFPLREQGLNFYAKELTTYEIEEFKKTKEAIRRFLLAYKMMLEFFGIKLTDKTGNVARAVNWQERFQHLNESQHNYLRITRILKSLGELGYESFKSPLVKFILHEALVENTIPNIKQSALEYFVYTIRDRRERRKLLRFAQKHYTPSENFIWGPPRKEQSEGSKAQKMSSPLASSHNSQTSMHKKAKDSKNSSSAVHLNSKTAEDKKVAPKEPVEETDRPSPEPSNEAAKPRNTEKDSNAENMNSQPEKTVTTPTEKKESVSPENNEEGGNDNQDNENPGNTNCHDVVLVQ
  
Inhibitor
Name:
BDBM182733
Synonyms:
US9145408, 360
Type:
Small organic molecule
Emp. Form.:
C25H31N3O3
Mol. Mass.:
421.5319
SMILES:
OC(=O)c1nc2ccccc2n(C2CC3CCC(C2)N3C2CC3CCCC(C3)C2)c1=O |TLB:19:20:27:23.24.25,11:12:15.16:19,20:19:12.18.13:15.16|
Structure:
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