Reaction Details Report a problem with these data
Target
Opioid growth factor receptor-like protein 1
Ligand
BDBM97711
Substrate
n/a
Meas. Tech.
ORL-1 GTPgammaS Binding Assay
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
57.2±3.1 nM
Comments
extracted
Citation
 Tsuno, N; Whitehead, JW; Yao, J Substituted-quinoxaline-type bridged-piperidine compounds as ORL-1 modulators US Patent  US9145408 Publication Date 9/29/2015 
Target
Name:
Opioid growth factor receptor-like protein 1
Synonyms:
OGFRL1 | OGRL1_HUMAN | Opioid Receptor-Like Receptor (ORL-1) | Opioid growth factor receptor-like protein 1 (ORL-1) | Opioid growth factor receptor-like protein 1 (ORL1) | Opioid receptor-like (ORL-1) | Opioid receptor-like (ORL1) | Opioid receptor-like protein 1 (OGL1) | Opioid receptor-like receptor (ORL1)
Type:
Protein
Mol. Mass.:
51247.53
Organism:
Homo sapiens (Human)
Description:
Q5TC84
Residue:
451
Sequence:
MGNLLGGVSFREPTTVEDCDSTWQTDSEPEPEEPGPGGGSEGPGQESEQPAQPPEQAGGRPGASPAPDEDAEAAGAEQGGDSTEATAKPKRSFYAARDLYKYRHQYPNFKDIRYQNDLSNLRFYKNKIPFKPDGVYIEEVLSKWKGDYEKLEHNHTYIQWLFPLREQGLNFYAKELTTYEIEEFKKTKEAIRRFLLAYKMMLEFFGIKLTDKTGNVARAVNWQERFQHLNESQHNYLRITRILKSLGELGYESFKSPLVKFILHEALVENTIPNIKQSALEYFVYTIRDRRERRKLLRFAQKHYTPSENFIWGPPRKEQSEGSKAQKMSSPLASSHNSQTSMHKKAKDSKNSSSAVHLNSKTAEDKKVAPKEPVEETDRPSPEPSNEAAKPRNTEKDSNAENMNSQPEKTVTTPTEKKESVSPENNEEGGNDNQDNENPGNTNCHDVVLVQ
  
Inhibitor
Name:
BDBM97711
Synonyms:
US8476271, 17 | US8846929, 360 | US8846929, 361 | US9145408, 361
Type:
Small organic molecule
Emp. Form.:
C25H31N3O3
Mol. Mass.:
421.5319
SMILES:
OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3C2CC3CCCC(C3)C2)c1=O |r,THB:19:20:27:24.23.25|
Structure:
Search PDB for entries with ligand similarity: