Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM182732
Substrate
n/a
Meas. Tech.
Mu-Opioid GTPgammaS Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
EC50
>20000±n/a nM
Comments
extracted
Citation
 Tsuno, N; Whitehead, JW; Yao, J Substituted-quinoxaline-type bridged-piperidine compounds as ORL-1 modulators US Patent  US9145408 Publication Date 9/29/2015 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM182732
Synonyms:
US9145408, 405
Type:
Small organic molecule
Emp. Form.:
C27H34N3O3
Mol. Mass.:
448.5777
SMILES:
C[C@H]1C[C@H]2C[C@@H](C1)C[C@@H](C2)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(C([O-])=O)c1=O |r,THB:8:10:18.16.17:12.14.13|
Structure:
Search PDB for entries with ligand similarity: