Reaction Details Report a problem with these data
Target
Ferrochelatase, mitochondrial [R115L]
Ligand
BDBM25013
Substrate
n/a
Meas. Tech.
Competition Binding Assays
Kd
2.7e+3±n/a nM
Citation
 Klaeger, S; Gohlke, B; Perrin, J; Gupta, V; Heinzlmeir, S; Helm, D; Qiao, H; Bergamini, G; Handa, H; Savitski, MM; Bantscheff, M; Médard, G; Preissner, R; Kuster, B Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chem Biol 11:1245-54 (2016) [PubMed]  Article 
Target
Name:
Ferrochelatase, mitochondrial [R115L]
Synonyms:
FECH | Ferrochelatase R115L (FECH) | HEMH_HUMAN
Type:
Protein
Mol. Mass.:
47832.73
Organism:
Homo sapiens (Human)
Description:
Mutant R115L used for experiment
Residue:
423
Sequence:
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQVQPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQL
  
Inhibitor
Name:
BDBM25013
Synonyms:
4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol | GSK-690693 | GSK690693 | US10550114, Compound GSK690693
Type:
Small organic molecule
Emp. Form.:
C21H27N7O3
Mol. Mass.:
425.4842
SMILES:
CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N |r|
Structure:
Search PDB for entries with ligand similarity: