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Target
Tyrosine-protein kinase ABL1 [229-512]
Ligand
BDBM185673
Substrate
n/a
Meas. Tech.
Kinome-Wide Inhibitor Profiling
Kd
0.32±0.02 nM
Citation
 Kwarcinski, FE; Brandvold, KR; Phadke, S; Beleh, OM; Johnson, TK; Meagher, JL; Seeliger, MA; Stuckey, JA; Soellner, MB Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. ACS Chem Biol 11:1296-304 (2016) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase ABL1 [229-512]
Synonyms:
ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 (c-Abl)
Type:
Protein
Mol. Mass.:
32850.19
Organism:
Homo sapiens (Human)
Description:
Human c-Abl kinase domain (229-512aa)
Residue:
284
Sequence:
SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGK
  
Inhibitor
Name:
BDBM185673
Synonyms:
DAS-CHO-II
Type:
Small organic molecule
Emp. Form.:
C28H31N7O3S
Mol. Mass.:
545.656
SMILES:
Cc1nc(Nc2ncc(s2)C(=O)Nc2ccc(Oc3ccccc3)cc2C)cc(n1)N1CCN(CCO)CC1
Structure:
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