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Target
Tyrosine-protein kinase ABL1 [229-512]
Ligand
BDBM185674
Substrate
n/a
Meas. Tech.
Kinome-Wide Inhibitor Profiling
Kd
7.2±0.1 nM
Citation
 Kwarcinski, FE; Brandvold, KR; Phadke, S; Beleh, OM; Johnson, TK; Meagher, JL; Seeliger, MA; Stuckey, JA; Soellner, MB Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. ACS Chem Biol 11:1296-304 (2016) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase ABL1 [229-512]
Synonyms:
ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 (c-Abl)
Type:
Protein
Mol. Mass.:
32850.19
Organism:
Homo sapiens (Human)
Description:
Human c-Abl kinase domain (229-512aa)
Residue:
284
Sequence:
SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGK
  
Inhibitor
Name:
BDBM185674
Synonyms:
4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide | Rebastinib
Type:
Small organic molecule
Emp. Form.:
C30H28FN7O3
Mol. Mass.:
553.5868
SMILES:
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc4ncccc4c3)C(C)(C)C)c(F)c2)ccn1
Structure:
Search PDB for entries with ligand similarity: