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Target
D(2) dopamine receptor
Ligand
BDBM185678
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.4±n/a
Ki
4.6±0.6 nM
Comments
extracted
Citation
 Jin, J; Roth, B; Frye, S Functionally selective ligands of dopamine D2 receptors US Patent  US9156822 Publication Date 10/13/2015 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM185678
Synonyms:
UNC10099984 | US9156822, 6
Type:
Small organic molecule
Emp. Form.:
C24H29Cl2N3O2
Mol. Mass.:
462.412
SMILES:
Clc1cccc(N2CCCN(CCCCOc3ccc4CCNC(=O)c4c3)CC2)c1Cl
Structure:
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