Reaction Details Report a problem with these data
Target
Dihydrolipoyl dehydrogenase
Ligand
BDBM34905
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7±n/a
IC50
<40±n/a nM
Comments
extracted
Citation
 Wong, C; Wu, Y Compounds and methods for treating tuberculosis infection US Patent  US9073941 Publication Date 7/7/2015 
Target
Name:
Dihydrolipoyl dehydrogenase
Synonyms:
DLDH_MYCTU | Lipoamide Dehydrogenase (Lpd) | lpd | lpdC
Type:
Enzyme
Mol. Mass.:
49231.98
Organism:
Mycobacterium tuberculosis
Description:
P9WHH9
Residue:
464
Sequence:
MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFADANTLLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIADGGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEALQECFHGLVGHMINF
  
Inhibitor
Name:
BDBM34905
Synonyms:
1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazine-5,7-quinone | 1,6-dimethyl-3-propylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | MLS000718932 | SMR000291200 | US9073941, 617 | cid_3164059
Type:
Small organic molecule
Emp. Form.:
C10H13N5O2
Mol. Mass.:
235.2425
SMILES:
CCCc1nn(C)c2nc(=O)n(C)c(=O)c2n1
Structure:
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