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Target
Tyrosine-protein kinase BTK
Ligand
BDBM288486
Substrate
n/a
Meas. Tech.
Btk Enzyme Activity Assay
IC50
0.510±n/a nM
Citation
 Liu, J; Kozlowski, JA; Alhassan, A; Boga, SB; Gao, X; Guiadeen, DG; Wang, J; Yu, W; Cai, J; Liu, S; Wang, D; Wu, H; Yang, C Benzamide imidazopyrazine Btk inhibitors US Patent  US10087188 Publication Date 10/2/2018 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM288486
Synonyms:
6-[8-amino-1-(2- ethoxy-4-{[4- (trifluoromethyl) pyridin-2- yl]carbamoyl}phenyl) imidazo[1,5-a]pyrazin- 3- yl]spiro[3.3]heptane- 2-carboxylic acid | US10087188, Example 93
Type:
Small organic molecule
Emp. Form.:
C29H27F3N6O4
Mol. Mass.:
580.5577
SMILES:
CCOc1cc(ccc1-c1nc(C2CC3(CC(C3)C(O)=O)C2)n2ccnc(N)c12)C(=O)Nc1cc(ccn1)C(F)(F)F |(2.65,-2.91,;1.56,-1.82,;1.96,-.33,;.87,.76,;1.27,2.25,;.18,3.34,;-1.31,2.94,;-1.71,1.45,;-.62,.36,;-1.01,-1.13,;-.11,-2.37,;-1.01,-3.62,;-.62,-5.11,;-1.39,-6.44,;-.05,-7.21,;-.82,-8.54,;.51,-9.31,;1.28,-7.98,;.91,-10.8,;2.4,-11.2,;-.18,-11.89,;.72,-5.88,;-2.48,-3.14,;-3.81,-3.91,;-5.15,-3.14,;-5.15,-1.6,;-3.81,-.83,;-3.81,.71,;-2.48,-1.6,;.58,4.82,;-.51,5.91,;2.07,5.22,;2.84,6.56,;2.07,7.89,;2.84,9.22,;4.38,9.22,;5.15,7.89,;4.38,6.56,;2.07,10.56,;.53,10.56,;2.84,11.89,;3.61,10.56,)|
Structure:
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