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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM188792
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.2±n/a
IC50
<100±n/a nM
Comments
extracted
Citation
 McElroy, WT; Li, G; Ho, GD; Tan, Z; Paliwal, S; Seganish, WM; Tulshian, D; Lampe, J; Methot, JL; Zhou, H; Altman, MD; Zhu, L Amidopyrazole inhibitors of interleukin receptor-associated kinases US Patent  US9169260 Publication Date 10/27/2015 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM188792
Synonyms:
US9169260, 58
Type:
Small organic molecule
Emp. Form.:
C25H28FN7O
Mol. Mass.:
461.5345
SMILES:
CC(C)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cc1F
Structure:
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