Reaction Details Report a problem with these data
Target
Thyrotropin subunit beta
Ligand
BDBM189329
Substrate
n/a
Meas. Tech.
Antagonist Activity Assay
IC50
192±0.0 nM
Citation
 Karstens, WF; Conti, PG; Timmers, CM; Plate, R; Van Koppen, CJ TSH receptor antagonizing tetrahydroquinoline compounds US Patent  US9174940 Publication Date 11/3/2015 
Target
Name:
Thyrotropin subunit beta
Synonyms:
TSHB | TSHB_BOVIN | Thyroid-stimulating hormone subunit beta (bTSH)
Type:
Enzyme
Mol. Mass.:
15628.77
Organism:
Bos taurus (Bovine)
Description:
P01223
Residue:
138
Sequence:
MTATFLMSMIFGLACGQAMSFCIPTEYMMHVERKECAYCLTINTTVCAGYCMTRDVNGKLFLPKYALSQDVCTYRDFMYKTAEIPGCPRHVTPYFSYPVAISCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYMVGFSI
  
Inhibitor
Name:
BDBM189329
Synonyms:
(+)-(1-Acetyl-4-methyl-4-phenyl-1,2,3,4-tetrahydro-quinolin-6-yl)-carbamic acid 3-chloro-4-fluoro-benzyl ester (Compound C) | US9174940, Compound C
Type:
Small organic molecule
Emp. Form.:
C26H24ClFN2O3
Mol. Mass.:
466.932
SMILES:
CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)OCc3ccc(F)c(Cl)c3)ccc12
Structure:
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