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Target
Serine/threonine-protein kinase Sgk1
Ligand
BDBM189806
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
1050±n/a nM
Citation
 Nazare, M; Halland, N; Schmidt, F; Weiss, T; Dietz, U; Hofmeister, A N-[4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides and their use as pharmaceuticals US Patent  US9174993 Publication Date 11/3/2015 
Target
Name:
Serine/threonine-protein kinase Sgk1
Synonyms:
SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1)
Type:
Other Protein Type
Mol. Mass.:
48954.40
Organism:
Homo sapiens (Human)
Description:
Recombinant human SGK-1 enzyme produced in a baculovirus system.
Residue:
431
Sequence:
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
  
Inhibitor
Name:
BDBM189806
Synonyms:
US9174993, 43
Type:
Small organic molecule
Emp. Form.:
C21H20Cl2N10O4S2
Mol. Mass.:
611.484
SMILES:
Cc1nn(C)c(Cl)c1S(=O)(=O)Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2c(C)nn(C)c2Cl)cc1
Structure:
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