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Target
Transient receptor potential cation channel subfamily V member 3
Ligand
BDBM190585
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<200±n/a nM
Citation
 Moran, MM; Chong, JA; Fanger, C; Ripka, AS; Larsen, GR; Zhen, X; Underwood, DJ; Weigele, M Compounds of modulating TRPV3 function US Patent  US9181219 Publication Date 11/10/2015 
Target
Name:
Transient receptor potential cation channel subfamily V member 3
Synonyms:
TRPV3 | TRPV3_HUMAN | Transient receptor potential cation channel subfamily V member 3 (TRPV3) | Vanilloid receptor-like 3
Type:
Enzyme
Mol. Mass.:
90635.51
Organism:
Homo sapiens (Human)
Description:
Q8NET8
Residue:
790
Sequence:
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV
  
Inhibitor
Name:
BDBM190585
Synonyms:
US9181219, 2-{[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}-1-(8-methyl-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one
Type:
Small organic molecule
Emp. Form.:
C18H16F4N2OS
Mol. Mass.:
384.391
SMILES:
Cc1cccc2CCCN(C(=O)CSc3ncc(cc3F)C(F)(F)F)c12
Structure:
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