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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM191129
Substrate
n/a
Meas. Tech.
Trans-Phosphorylation Assay
pH
7.5±n/a
IC50
1±n/a nM
Comments
extracted
Citation
 Casuscelli, F; Badari, A; Orrenius, SC; Piutti, C; Disingrini, T Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones as protein kinase inhibitors US Patent  US9181258 Publication Date 11/10/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM191129
Synonyms:
US9181258, 130
Type:
Small organic molecule
Emp. Form.:
C25H25F3N4O2
Mol. Mass.:
470.4868
SMILES:
NCC[C@H]1CNC(=O)c2cc(c(-c3ccc(cc3)C3(N)CC3)n12)-c1cccc(OC(F)(F)F)c1
Structure:
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