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Target
Collagenase 3
Ligand
BDBM191771
Substrate
n/a
Meas. Tech.
In vitro MMP-8 Assay
Temperature
310.15±n/a K
IC50
45000±n/a nM
Comments
extracted
Citation
 Johnson, F; Golub, L Curcumin analogues as zinc chelators and their uses US Patent  US9187406 Publication Date 11/17/2015 
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Homo sapiens (Human)
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
  
Inhibitor
Name:
BDBM191771
Synonyms:
US9187406, Compound 8
Type:
Small organic molecule
Emp. Form.:
C31H33N3O3
Mol. Mass.:
495.612
SMILES:
CN(C)Cc1ccc(\C=C\C(=O)C(C(=O)Nc2ccccc2)C(=O)\C=C\c2ccc(cc2)N(C)C)cc1
Structure:
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