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Target
Carbonic anhydrase 2
Ligand
BDBM193793
Substrate
n/a
Meas. Tech.
Carbonic Anhydrase (bCAII) Inhibition Assay
pH
7.2±n/a
IC50
9.036e+4± 2.78e+3 nM
Comments
extracted
Citation
 Imran, S; Taha, M; Ismail, NH; Fayyaz, S; Khan, KM; Choudhary, MI Synthesis of novel bisindolylmethanes: New carbonic anhydrase II inhibitors, docking, and 3D pharmacophore studies. Bioorg Chem 68:90-104 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA2 | CAH2_BOVIN | Carbonic anhydrase | Carbonic anhydrase 2 | Carbonic anhydrase II | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29115.93
Organism:
Bos taurus
Description:
n/a
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIANGERQSPVDIDTKAVVQDPALKPLALVYGEATSRRMVNNGHSFNVEYDDSQDKAVLKDGPLTGTYRLVQFHFHWGSSDDQGSEHTVDRKKYAAELHLVHWNTKYGDFGTAAQQPDGLAVVGVFLKVGDANPALQKVLDALDSIKTKGKSTDFPNFDPGSLLPNVLDYWTYPGSLTTPPLLESVTWIVLKEPISVSSQQMLKFRTLNFNAEGEPELLMLANWRPAQPLKNRQVRGFPK
  
Inhibitor
Name:
BDBM193793
Synonyms:
N-(4-(bis(5-bromo-1H-indol-3-yl)methyl)phenyl)naphthalene-2-sulfonamide (4c)
Type:
Small organic molecule
Emp. Form.:
C33H23Br2N3O2S
Mol. Mass.:
685.428
SMILES:
Brc1ccc2[nH]cc(C(c3c[nH]c4ccc(Br)cc34)c3ccc(NS(=O)(=O)c4ccc5ccccc5c4)cc3)c2c1
Structure:
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