Reaction Details
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Transitional endoplasmic reticulum ATPase
Ligand
BDBM194609
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
Temperature
310.15±n/a K
IC50
328±n/a nM
Comments
extracted
Citation
Kakizuka, A; Hori, S; Ikeda, H; Yoshimura, N; Nakano, N; Shudo, T; Fuchigami, T Agent for treatment of eye diseases US Patent US9206129 Publication Date 12/8/2015 More Info.:
Target
Name:
Transitional endoplasmic reticulum ATPase
Synonyms:
TERA_MOUSE | Valosin-containing protein (VCP) | Vcp
Type:
Protein
Mol. Mass.:
89300.63
Organism:
Mus musculus (Mouse)
Description:
Q01853
Residue:
806
Sequence:
MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGAGPSQGSGGGTGGSVYTEDNDDDLYG
Inhibitor
Name:
BDBM194609
Synonyms:
US9206129, 25
Type:
Small organic molecule
Emp. Form.:
C26H21N4NaO6S
Mol. Mass.:
540.523
SMILES:
COC(=O)CCC(=O)c1ccc(cc1)-c1ccc(cn1)\N=N\c1cc(c2ccccc2c1N)S(=O)(=O)O[Na]
Structure:
