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Target
D(2) dopamine receptor
Ligand
BDBM194816
Substrate
n/a
Meas. Tech.
Dopamine D2 Receptor Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
1.2±n/a nM
Comments
extracted
Citation
 Yamashita, H; Ito, N; Miyamura, S; Oshima, K; Matsubara, J; Kuroda, H; Takahashi, H; Shimizu, S; Tanaka, T Piperazine-substituted benzothiophenes for treatment of mental disorders US Patent  US9206167 Publication Date 12/8/2015 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM194816
Synonyms:
US9206167, 38 | USRE48059, Compound of Example 38
Type:
Small organic molecule
Emp. Form.:
C26H29N3O2S
Mol. Mass.:
447.592
SMILES:
COc1ccc2ccn(CCCCN3CCN(CC3)c3cccc4sccc34)c(=O)c2c1
Structure:
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