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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM195569
Substrate
n/a
Meas. Tech.
MAO-A and MAO-B Fluorescence Assay
pH
7.4±n/a
IC50
4.4± 0.6 nM
Comments
extracted
Citation
 Nel, MS; Petzer, A; Petzer, JP; Legoabe, LJ 2-Heteroarylidene-1-indanone derivatives as inhibitors of monoamine oxidase. Bioorg Chem 69:20-28 (2016) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM195569
Synonyms:
(2E)-2-[(5-Bromofuran-2-yl)methylidene]-5-methoxy-2,3-dihydro-1H-inden-1-one (11o)
Type:
Small organic molecule
Emp. Form.:
C15H11BrO3
Mol. Mass.:
319.15
SMILES:
COc1ccc2C(=O)\C(Cc2c1)=C\c1ccc(Br)o1
Structure:
Search PDB for entries with ligand similarity: