Reaction Details Report a problem with these data
Target
DNA polymerase
Ligand
BDBM51365
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
4100±n/a nM
Comments
extracted
Citation
 Ricciardi, RP Therapeutic compounds for blocking DNA synthesis of POX viruses US Patent  US9211296 Publication Date 12/15/2015 
Target
Name:
DNA polymerase
Synonyms:
DNA Synthesis | DPOL_VACCW | OPG071 | POL
Type:
Enzyme
Mol. Mass.:
116939.47
Organism:
Vaccinia virus (strain WR)
Description:
P06856
Residue:
1006
Sequence:
MDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEIYQSLSPPPFNARPLGKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRSIQNATMDEFLNISWFYISNGISPDGCYSLDEQYLTKINNGCYHCDDPRNCFAKKIPRFDIPRSYLFLDIECHFDKKFPSVFINPISHTSYCYIDLSGKRLLFTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCSEIVLLRIAKQLLELTFDYVVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVYLCIYERNQSSHKGVGGMANTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSISKNAFSCMGKVLNRGVREMTFIGDDTTDAKGKAAAFAKVLTTGNYVTVDEDIICKVIRKDIWENGFKVVLLCPTLPNDTYKLSFGKDDVDLAQMYKDYNLNIALDMARYCIHDACLCQYLWEYYGVETKTDAGASTYVLPQSMVFEYRASTVIKGPLLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKMFSNNVLIFDYNSLYPNVCIFGNLSPETLVGVVVSTNRLEEEINNQLLLQKYPPPRYITVHCEPRLPNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTEKAIYDSMQYTYKIVANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLESVLNGAELSNGMLRFANPLSNPFYMDDRDINPIVKTSLPIDYRFRFRSVYGDTDSVFTEIDSQDVDKSIEIAKELERLINNRVLFNNFKIEFEAVYKNLIMQSKKKYTTMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKTYKTRLSEMLSEGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHSNYKSADNPNMYLVTEYNKNNPETIELGERYYFAYICPANVPWTKKLVNIKTYETIIDRSFKLGSDQRIFYEVYFKRLTSEIVNLLDNKVLCISFFERMFGSKPTFYEA
  
Inhibitor
Name:
BDBM51365
Synonyms:
1-N-benzo[g]quinolin-4-yl-4-N-propan-2-ylbenzene-1,4-diamine | MLS000766754 | N-benzo[g]quinolin-4-yl-N'-isopropylbenzene-1,4-diamine | N1-(4-benzo[g]quinolinyl)-N4-propan-2-ylbenzene-1,4-diamine | N1-benzo[g]quinolin-4-yl-N4-propan-2-yl-benzene-1,4-diamine | SMR000339650 | US9211296, Table 7, Compd: 7 | benzo[g]quinolin-4-yl-[4-(isopropylamino)phenyl]amine | cid_182785
Type:
Small organic molecule
Emp. Form.:
C22H21N3
Mol. Mass.:
327.4222
SMILES:
CC(C)Nc1ccc(Nc2ccnc3cc4ccccc4cc23)cc1
Structure:
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