Reaction Details Report a problem with these data
Target
Histone deacetylase 6 [440-798]
Ligand
BDBM19149
Substrate
n/a
Meas. Tech.
HDAC6 fluorescence anisotropy assay
Temperature
298.15±n/a K
Ki
0.6±0.2 nM
IC50
1.1±0.3 nM
Comments
extracted
Citation
 Hai, Y; University of Pennsylvania,, DW Histone deacetylase 6 structure and molecular basis of catalysis and inhibition Nat Chem Biol 12:741-747 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 6 [440-798]
Synonyms:
Catalytic domain 2 (zCD2) | zCD2
Type:
n/a
Mol. Mass.:
39850.25
Organism:
Danio rerio
Description:
F8W4B7[440-798]
Residue:
359
Sequence:
SSPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
  
Inhibitor
Name:
BDBM19149
Synonyms:
CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA | US10011611, SAHA | US10188756, Compound SAHA | US11207431, SAHA | US11505523, Compound SAHA | US9115116, SAHA | US9353061, SAHA | US9428447, SAHA | US9695181, Vorinostat | Vorinostat | Zolinza | cid_5311 | suberoylanilide hydroxamic acid
Type:
Small organic molecule
Emp. Form.:
C14H20N2O3
Mol. Mass.:
264.3202
SMILES:
ONC(=O)CCCCCCC(=O)Nc1ccccc1
Structure:
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