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Target
L-lactate dehydrogenase A chain
Ligand
BDBM50052254
Substrate
n/a
Meas. Tech.
LHDA/LDHB Enzymatic Assays
IC50
8.7e+2±n/a nM
Citation
 Boudreau, A; Purkey, HE; Hitz, A; Robarge, K; Peterson, D; Labadie, S; Kwong, M; Hong, R; Gao, M; Del Nagro, C; Pusapati, R; Ma, S; Salphati, L; Pang, J; Zhou, A; Lai, T; Li, Y; Chen, Z; Wei, B; Yen, I; Sideris, S; McCleland, M; Firestein, R; Corson, L; Vanderbilt, A; Williams, S; Daemen, A; Belvin, M; Eigenbrot, C; Jackson, PK; Malek, S; Hatzivassiliou, G; Sampath, D; Evangelista, M; O'Brien, T Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nat Chem Biol 12:779-86 (2016) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase A chain
Synonyms:
Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:
Protein
Mol. Mass.:
36694.85
Organism:
Homo sapiens (Human)
Description:
P00338::PDB Code: 4ajp
Residue:
332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
  
Inhibitor
Name:
BDBM50052254
Synonyms:
2',6'-dichloro-4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,1'-biphenyl]-3(2H)-one (3) | CHEMBL3318469
Type:
Small organic molecule
Emp. Form.:
C18H13Cl3O2S
Mol. Mass.:
399.719
SMILES:
OC1=C(Sc2ccccc2Cl)C(=O)CC(C1)c1c(Cl)cccc1Cl |c:1|
Structure:
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