Reaction Details Report a problem with these data
Target
Nicotinamide N-methyltransferase
Ligand
BDBM60924
Substrate
n/a
Meas. Tech.
NNMT Enzymatic Activity Assay
pH
8.6±n/a
Temperature
310.15±n/a K
Ki
97000000±35000000 nM
Comments
extracted
Citation
 van Haren, MJ; Sastre Toraņo, J; Sartini, D; Emanuelli, M; Parsons, RB; Martin, NI A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase. Biochemistry 55:5307-15 (2016) [PubMed]  Article 
Target
Name:
Nicotinamide N-methyltransferase
Synonyms:
NNMT | NNMT_HUMAN | Nicotinamide N-methyltransferase | Nicotinamide N-methyltransferase (NNMT)
Type:
Protein
Mol. Mass.:
29571.16
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
264
Sequence:
MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL
  
Inhibitor
Name:
BDBM60924
Synonyms:
quinoline 3-carboxamide
Type:
n/a
Emp. Form.:
C10H8N2O
Mol. Mass.:
172.1833
SMILES:
NC(=O)c1cnc2ccccc2c1
Structure:
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