Reaction Details
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Nicotinamide N-methyltransferase
Ligand
BDBM197172
Substrate
n/a
Meas. Tech.
NNMT Enzymatic Activity Assay
pH
8.6±n/a
Temperature
310.15±n/a K
IC50
2.63e+4± 4.4e+3 nM
Comments
extracted
Citation
van Haren, MJ; Sastre Toraņo, J; Sartini, D; Emanuelli, M; Parsons, RB; Martin, NI A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase. Biochemistry 55:5307-15 (2016) [PubMed] Article More Info.:
Target
Name:
Nicotinamide N-methyltransferase
Synonyms:
NNMT | NNMT_HUMAN | Nicotinamide N-methyltransferase | Nicotinamide N-methyltransferase (NNMT)
Type:
Protein
Mol. Mass.:
29571.16
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
264
Sequence:
MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL
Inhibitor
Name:
BDBM197172
Synonyms:
AdoHcy
Type:
Small organic molecule
Emp. Form.:
C15H23N6O5S
Mol. Mass.:
399.445
SMILES:
C[S+](CCC([NH3+])C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|
Structure:
