Reaction Details Report a problem with these data
Target
Ghrelin O-acyltransferase
Ligand
BDBM289086
Substrate
n/a
Meas. Tech.
Human GOAT Enzymatic Assay
pH
7.5±n/a
IC50
69.5±0.6 nM
Comments
extracted
Citation
 Galka, CS; Hembre, EJ; Honigschmidt, NA; Martinez-Grau, MA; Plaza, GR; Rubio, A Ghrelin O-acyl transferase inhibitors US Patent  US10093651 Publication Date 10/9/2018 
Target
Name:
Ghrelin O-acyltransferase
Synonyms:
GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4
Type:
Enzyme
Mol. Mass.:
49733.10
Organism:
Homo sapiens (Human)
Description:
Q96T53
Residue:
435
Sequence:
MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYAVLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITLSSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSLCSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFECIYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRISVFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYLIHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVYCILLLLLAKRKHKCN
  
Inhibitor
Name:
BDBM289086
Synonyms:
N-[(1 S)-2-[4-[2-[4-Amino-6-methyl-2-(trifluoromethyl)pyrimidin-5-yl]ethyl]-1-piperidyl]-1-methyl-2-oxo-ethyl]-2-methyl-pyrazole-3-carboxamide | US10093651, Example 2
Type:
Small organic molecule
Emp. Form.:
C21H28F3N7O2
Mol. Mass.:
467.4879
SMILES:
C[C@H](NC(=O)c1ccnn1C)C(=O)N1CCC(CCc2c(C)nc(nc2N)C(F)(F)F)CC1 |r|
Structure:
Search PDB for entries with ligand similarity: