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Target
Ghrelin O-acyltransferase
Ligand
BDBM289087
Substrate
n/a
Meas. Tech.
Human GOAT Enzymatic Assay
pH
7.5±n/a
IC50
55.7±0.6 nM
Comments
extracted
Citation
 Galka, CS; Hembre, EJ; Honigschmidt, NA; Martinez-Grau, MA; Plaza, GR; Rubio, A Ghrelin O-acyl transferase inhibitors US Patent  US10093651 Publication Date 10/9/2018 
Target
Name:
Ghrelin O-acyltransferase
Synonyms:
GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4
Type:
Enzyme
Mol. Mass.:
49733.10
Organism:
Homo sapiens (Human)
Description:
Q96T53
Residue:
435
Sequence:
MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYAVLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITLSSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSLCSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFECIYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRISVFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYLIHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVYCILLLLLAKRKHKCN
  
Inhibitor
Name:
BDBM289087
Synonyms:
N-[(1S)-2-[4-[2-[4-Amino- 6-methyl-2- (trifluoromethyl)pyrimidin- 5-yl]ethyl]-1-piperidyl]- 1-methyl-2-oxo-ethyl]-3- chloro-pyrazine-2- carboxamide | US10093651, Example 15
Type:
Small organic molecule
Emp. Form.:
C21H25ClF3N7O2
Mol. Mass.:
499.917
SMILES:
C[C@H](NC(=O)c1nccnc1Cl)C(=O)N1CCC(CCc2c(C)nc(nc2N)C(F)(F)F)CC1 |r|
Structure:
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